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Pelletization Line

Pelletization Line refers to the production setup used to create small, spherical pellets or granules that are often used in drug formulation. These pellets can be used for various purposes, such as controlled or sustained-release drug delivery systems, where the medication is released slowly over time.

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Working Principal of

Pelletization Line

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Pelletization is a crucial process in the pharmaceutical industry, particularly for developing controlled-release and sustained-release formulations.

Pellets are small, spherical, or semi-spherical solid dosage forms that provide various advantages over traditional tablets or capsules, such as more uniform drug distribution, better flow properties, and the ability to combine multiple drugs in one dosage form.

The Pelletization Line is a sophisticated and integrated production setup used to convert raw materials into uniform pellets. Understanding how a pelletization line functions requires a deep dive into the various components, processes, and technologies involved.

This exploration will cover the preparation, processing, and final packaging of pharmaceutical pellets, highlighting the critical role each step plays in ensuring the quality and effectiveness of the final product.

Working of Pelletization Line

Sifter- To maintain uniform granule size, We have single & twin deck models with validated sieved in mesh & microns size as per BSS O ASTM standard.

Granulation (Wet/ Dry)- Material collected bin will be lifted and positioned above the sigma mixer and then the material will be charged in the sigma mixer

IPC BIN- For uniform mixing of material along with liquid charging port assembly to charge liquid binder

Solid Drug Layering- Material collecting bin will be placed at the discharge point of the sigma mixer and will be lifted to be at the feeding position of wet mass dispenser

Extrusion & Spheronization- For Uniformly charging material to the Basket Extruder

Fluid Bed Coating / Drying- For preparing extrudes

Sifter- Material from the basket extruder will be collected in the FBD bowl and it will be further assembled with the FBD

Lifting Tilting Device- For drying extrudes

Blending- After drying, the same FBD bowl will be connect to the tippler system and the tippler will lift the bowl and will be placed at the feeding positing the shifter

Capsule Filling- For separating the oversized, actual sized & lower sized extrudes

Pelletization Line Overview

Throughput for

Pelletization Line

Model

Capacity

Palletization line

200 to 600 kg/h

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Features of Pelletization Line

  • Controlled and Sustained Drug Release: Pellets can be engineered to release drugs at a controlled rate, improving therapeutic outcomes by maintaining steady drug levels in the bloodstream over time.
  • Scalable Manufacturing: Pelletization processes are easily scalable from laboratory to commercial production, making it a cost-effective option for large-scale manufacturing.
  • Improved Flow Properties: Pellets have excellent flow characteristics, making them easier to handle and process during manufacturing, especially for filling capsules or sachets.
  • Versatility in Formulation: Pelletization is suitable for a wide range of APIs, including those with poor compressibility, moisture sensitivity, or a need for taste masking.
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Advantages of using

Pelletization Line

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1. Dose Uniformity:

Each pellet contains a precise amount of the active ingredient, ensuring consistent dosing and reducing the risk of under- or over-dosing.

2. Combination Therapies:

Different drugs can be incorporated into separate pellets within a single dosage form, enabling the delivery of multiple medications simultaneously without interactions.

3. Improved Bioavailability:

Pellets can be designed to release drugs at specific sites within the gastrointestinal tract, enhancing absorption and bioavailability.

4. Enhanced Stability:

he process can protect sensitive drugs from degradation due to moisture, light, or pH, extending the product's shelf life.

5. Reduced Side Effects:

Controlled-release pellets minimize the peak concentrations of drugs in the bloodstream, potentially reducing the risk of side effects.

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Pelletization Line

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