An integrated extrusion and spheronization machine optimizes the granulation process by seamlessly combining extrusion and spheronization into a continuous operation. It precisely transforms materials into uniformly shaped granules through controlled extrusion and spheronization stages. With 21 CFR Part compliance for secure data management and enhanced repeatability, the equipment minimizes material loss and ensures consistent, high-quality results, boosting productivity and process reliability.
Thus, integration is designed for continuous operation.
The extrusion operation can be considered a wet granulation technique, applying pressure to a mass until it flows through a die, which determines the dimensions of the agglomerated particles.
The extrudate length is the dimensional variable.
The extruded granules must exhibit characteristics of cohesiveness, firmness, and plasticity.
This process is divided into three stages: breaking the cylindrical segments (or extrudate), agglomeration of the broken segments, and smoothing of the particles.
Breaking of the cylindrical segments occurs due to interactions with the rotating chequered plate, the stationary drum wall, and other extrudate particles.
Agglomeration happens when smaller fragments from the breaking stage are picked up by larger granules during smoothing.
Spherical particles are formed during the smoothing stage through rotational motion of each granule about its axis and constant plane changes.
10-15 kg
20-40 kg
50-70 kg
80-120 kg
150-180 kg
200-300 kg
All machines
Integrates extrusion and spheronization into a single continuous process, eliminating the need for intermediate steps and reducing production cycle times.
Produces spherical granules with precise control over size distribution and shape, ensuring uniformity in dosage form attributes.
Features durable construction and reliable performance, minimizing downtime and maintenance requirements.
Facilitates rapid formulation development, process optimization, and scale-up capabilities, accelerating time-to-market for new products.
Scales easily from pilot-scale to full-scale production, accommodating varying production volumes and demands.
Expert Recommendations
Our team of specialists is prepared to assist you in discovering customized solutions that fit your unique requirements.