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Capacity
Payload, Volume throughput,..
Utility Specs
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Configuration
Modular, Standalone, inline, or rotary.
Build Quality
Material grade, wear resistance.
The Hot-Melt Extrusion (HME) technique, initially developed in the 18th century for lead pipes, has become a versatile process used widely across plastics, rubber, and food industries. Today, over half of plastic products, such as bags and sheets, are made using HME, highlighting its adaptability. In pharmaceuticals, HME is a key method for creating various drug delivery systems. The process involves pumping raw materials through a heated barrel at controlled temperatures and pressures to produce uniform products. Pioneered by Breitenbach and advanced by Follonier, HME excels in creating sustained-release polymer-based pellets. FEATURES Key Steps in HME: 1. Feeding: Raw materials are introduced via a hopper. 2. Mixing & Grinding: Materials are mixed and ground to desired sizes. 3. Venting & Kneading: Ensures proper material processing and removal of gases. 4. Extrusion: The material flows through a heated barrel and is shaped by a die. Typically, the extruder has one or two rotating screws inside a stationary barrel, designed for optimal melting and shaping. The die at the end defines the final product shape, ensuring precise control over temperature, pressure, feeding rate, and screw speed for efficient material transformation. Discover the future of pharmaceutical manufacturing with Hot-Melt Extrusion (HME). Our innovative technology transforms drug delivery, creating precise molecular dispersions of active ingredients within polymer or lipid matrices. HME offers a versatile alternative for diverse dosage forms. Aligned with FDA's Process Analytical Technology, it ensures consistent, quality-controlled manufacturing. Explore the components, processing technologies, materials, and applications of HME in oral drug delivery systems – unlocking a new era in pharmaceutical excellence. Enhanced Solubility & Bioavailability: Improves the solubility and absorption of water-insoluble compounds, making them more effective. Uniform Particle Dispersion: Guarantees even distribution of fine particles throughout the extrudate. Stable Across Conditions: Maintains stability across varying pH levels and moisture conditions, ensuring reliable performance. Broad Dosage Forms: Capable of producing a wide variety of dosage forms, catering to diverse pharmaceutical needs. Flexible Screw Geometries: Utilizes various screw designs to adapt to different extrusion requirements, enhancing process flexibility. Fewer Unit Operations: Streamlines the manufacturing process by reducing the number of separate unit operations required. PERKS 1. Eco-Friendly & Solvent-Free: Operates without solvents and in nonambient conditions, reducing environmental impact and simplifying the process. 2. Cost-Effective & Efficient: Lowers production costs with reduced processing time and fewer steps, and supports continuous operation for greater efficiency. 3. Versatile Release Options: Supports sustained, modified, and targeted drug release, offering flexibility in pharmaceutical formulations. 4. Improved Content Uniformity: Ensures consistent quality and uniformity in the final extrudates. 5. No Compressibility Needed: Eliminates the need for compressibility of active ingredients, simplifying formulation.
| Model | UMSE-25/30 | UMSE-40/30 |
|---|---|---|
| Capacity | 2-5 kg | 15 - 20 kg |
INDIA - CORPORATE OFFICE
Unit No. 1, 2nd Floor, Vicino (Mega Mall), New Link Rd, Oshiwara, Andheri West, Mumbai, Maharashtra, India. 400102
MANUFACTURING FACILITY
Unit No. 1, Survey No. 52/2, NH8, Shirsad, Vajreshwari Road, Opp. Mandvi Police Station, Village - Mandvi, Taluka- Vasai, District- Palghar 401 303, India.
